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Profile
| Academic position | Full Professor |
|---|---|
| Research fields | Immunology,Evolutionary Cell and Developmental Biology (Zoology) |
| Keywords | stem cells, cell fate decisions, macrophages, cellular self renewal, regeneration |
Current contact address
| Country | Germany |
|---|---|
| City | Dresden |
| Institution | Technische Universität Dresden |
| Institute | Center for Regenerative Therapies Dresden (CRTD) |
Host during sponsorship
| Prof. Dr. Elly Tanaka | Technische Universität Dresden, Dresden |
|---|---|
| Prof. Dr.-Ing. habil. Dr. h.c. mult. Hans Müller-Steinhagen | Technische Universität Dresden, Dresden |
| Prof. Dr. Ezio Bonifacio | Technische Universität Dresden, Dresden |
| Prof. Dr.-Ing. habil. Dr. h.c. mult. Hans Müller-Steinhagen | Dresden International University GmbH, Dresden |
| Prof. Dr. Ursula M. Staudinger | Technische Universität Dresden, Dresden |
| Prof. Dr. Elly Tanaka | Research Institute of Molecular Pathology (IMP), Wien |
| Prof. Dr. Ezio Bonifacio | Biotechnologisches Zentrum (Biotec), Technische Universität Dresden, Dresden |
| Start of initial sponsorship | 01/04/2018 |
Programme(s)
| 2017 | Alexander von Humboldt Professorship |
|---|
Nominator's project description
| Our bodies are continually changing. In many organs – like the intestines, the skin or the blood – stem cells constantly create new cells to replace those that are lost. This is the way the tissue is preserved or regenerates after injury. Sieweke’s special field are the mechanisms by which cells of the immune system are generated and the role of these cells in preserving tissue function and regeneration. He has produced internationally recognised work that could help to develop new approaches to cellular therapy. It was Sieweke’s team, for example, who discovered an emergency mechanism which quickly responds to severe infections by supplying the body with new immune cells that fight the invading pathogens. These mechanisms might one day be used in bone marrow transplants to help rebuild the immune system more quickly. Sieweke’s research also showed that some mature immune cells, called macrophages, can divide indefinitely and keep up their numbers by using similar mechanisms as stem cells. The hope is that his research will help to activate these mechanisms when regeneration fails or to supply large numbers of macrophages for cellular therapies. Sieweke’s role as Humboldt Professor at Technische Universität Dresden will be to position the university more firmly at the interface of immunology and tissue regeneration and to drive new medical applications in this area. |